While on a trip to Hollywood to help a celebrity starlet's depressed Chihuahua, Maya Dolittle gets caught up in the Hollywood glitz. Dropping her dreams of becoming a vet, Maya lands a job hosting an animal talk show with famous heiress Tiffany Monaco. Lucky starts falling in love with a pedigreed pooch and Maya falls out of love with the ideas about how to help animals. Just when Maya thinks she'll be trapped forever in Tinseltown, Lucky, his new girlfriend and a whole herd of their animal friends spring, trot, fly and slither into action to save the day.